The paper presents the teaching of a Laboratory of Technological Design in which students are guided in a project experience, on a small scale, in which to verify the relationship between design and construction of architecture.The educational objective is to educate to a conscious planning in which the bonds are opportunities and Football the arch
Robustaflavone Isolated from Nandina domestica Using Bioactivity-Guided Fractionation Downregulates Inflammatory Mediators
Nandina domestica (Berberidaceae) has been used in traditional medicine for the treatment of cough.This plant is distributed in Korea, Japan, China, and India This study aimed to investigate the anti-inflammatory phytochemicals obtained from the N.domestica fruits.We isolated a biflavonoid-type phytochemical, robustaflavone (R), from N.domestica fr
Case Report: Sequential Combination Targeted Therapy With Type I and II MET Inhibitors in a Metastatic EGFR-Mutated, MET-Amplified NSCLC Patient With Acquired MET Y1230H Mutation
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard of care for advanced non-small-cell lung cancer (NSCLC) patients.However, most patients will eventually develop resistance.For EGFR-TKI Football resistance mediated by MET amplification, the combination of EGFR and MET TKIs has shown promising results in earl